Scientists have used artificial intelligence to predict how cancers will progress and evolve. This could help doctors design the most effective treatment for each patient. A team led by the Institute of Cancer Research London (ICR) and the University of Edinburgh developed a new technique known as Revolver (Repeated Evolution of Cancer).

This picks out patterns in DNA mutation within cancers and uses the information to forecast future genetic changes. The researchers said the ever-changing nature of tumors was one of the biggest challenges in treating cancer – with cancers often evolving to a drug-resistant form.

However, if doctors can predict how a tumor will evolve, they could intervene earlier to stop cancer in its tracks before it has had a chance to evolve or develop resistance, increasing the patient’s chances of survival.

Dr Andrea Sottoriva, who led the study and is team leader in evolutionary genomics and modelling at the ICR, said: “We’ve developed a powerful artificial intelligence tool which can make predictions about the future steps in the evolution of tumors based on certain patterns of mutation that have so far remained hidden within complex data sets. With this tool we hope to remove one of cancer’s trump cards – the fact that it evolves unpredictably, without us knowing what is going to happen next. By giving us a peek into the future, we could potentially use this AI tool to intervene at an earlier stage, predicting cancer’s next move.”

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